czwartek, 23 listopada 2006

Fazy cylku rozwojowego bakterii Cpn i jakie środki są skuteczne w poszczególnych fazach






EB  ( Elementary Body)
Podstawowe Ciało  - Co to takiego? EB to formy zarodnikowe które zarażają i posiadają minimalny metabolizm (nie używają substancji odżywczych, nie rozmnażają się, nie prowadzą wymianny z środowiskiem zewnętrznym itp). Są one odporne, małe i przebywają w [intercellular tissues] (na zewnątrz właściwych komórek ciała). Co takiego robią?  EB przyczepiają się do komórek twojego ciała i atakują je. Ponieważ może być wiecej EB niż może wejść do komórek, EB [ EB’s build up in local tissues causing inflammationi and immunei response.]

Co je zabija? Są zabijane przez "amoxicillini" która jest zamieniana w "penicilamine" w twoim ciele, i niszczy więźi które trzymają ścianę komórkową EB w całości. An amino acid NACi (N-acetyl cysteine) również jest używany w tym celu. Więc co się dzieje? Gdy je zabijasz, uwalniają one toksyny do twoich tkanek w których przebywały, 
co powoduje zapalenie i ból w tym miejscach, który może trwac przez dni lub tygodnie zanim poczujesz 
ulge. Większość ludzi biorących NAC mówi o okresach gdy mają uczucie jakby mieli
grypę, bóle, cieknący nos, czasem kaszel.



RB's- Reticulate Body - Co to takiego?  Gdy już EB dostanie się do komórki gospodarza, EB zamienia się w formę która moze  tworzyć nowe EB. Forma ta nazywa się własnie Reticulate Body or RB. RB nie posiadają własnego źródła energi by wykonywać swoje zadanie, więc muszą ją kraść (ATP) z komórki gospodarza, pozostawiając tym samym komórke gospodarza osłabioną i mniej funkcionalną. RB wpływa również na zdolnośc komórki do naturalnej śmierci, tak by móc spokojnie się rozmnażać.  Po wyprodukowaniu wielu nowych EB komórka gospodarza jest rozsadzana i ginie, rozprzestrzeniając zakaźliwe nowe EB w otaczającje tkanki.  RB są powstrzymywane przed rozmnażaniem przez różne antybiotyki takie jak doxycyclinei, azithromycini, roxythromycin i inne.  RB która jest poddawana takim antybiotykom zamieni się w "Cryptic (and nonreplicating) form"  w której to formie może być zabita przez metronidazolei.
RB są powstrzymywane przed powstawaniem przez rifamcini.


Cryptic form Co to za forma? Gdy RB są poddawane środowisku które zagraża ich przetrwaniu wewnątrz komórki (brak jedzenia, atak antybiotkyków, itp) mogą się zamienić w  formę "Cryptic" (zagadkowy) która pozostaje we wnętrzu komórki, ale jest tak jakby zahibernowana. Co takiego ona robi?
W tej formie standardowe antybiotyki jej nie zagrażają i może tak sobie pozostać dopuki
warunki się nie zmienią, wtedy znów stanie się RB i zacznie tworzyć nowe EB które sprawią
nawrót infekcji.  Więc co zabija Cryptic?  Flagyli (metronidazole) lub Tinactini (tinidazolei)
są używane w tym celu. Nitrofurantoin, an old urinary tract infection drug, also has antichalmydial effect in this phase.
Te leki mogą być ciężko tolerowane z różnych powodów, więc często są "podawane pulsacyjnie"
 poprzez
kurację 5 dniową co 3-4 tygodnie, w przeciwieństwie do ciągłego podawania.
 
Some protocolsi may eventually have one of these drugs taken continuously for some period as the patient can tolerate. Pacjencji mogą doświadczać zmęczenia, nausea, bowel upset, bólów stawów  i męśni ponieważ cryptic są zabijane i układ odpornościowy włącza się do akcji.

Wiele z dolegliwości podczas leczenia Cpn wynika z organism's endotxin itself, and the inflammation caused by your own immune system (cytokinei) reactions to that.
(chodzi o coś w stylu zapalenia wywoływanego przez własny system odpornościowy)


PODSUMOWANIE


Amoxicillan i NAC zabijają zaraźliwe formy bakteri (EB)  które umiejscowiły się w tkankach.

Rifamcin uniemożliwa EB’s transformację w  RB’s( in a vulnerable enzyme transformation phase.)

Doxycycline i  Rozithromycin lub Azithromycin, są używane w kombinacji by uniemożliwić
RB tworzenie nowych EB. Uzywane są dwa, gdyż dziłają na rózne proteinny a tym samym minimalizują szanse na wytworzenie odporności u bakteri

Suplementy są rekomendowane by pomóc zwalczyć wpływ CPN na ciało jak i  efekty zapalenia powodowanego przez wymieranie bakteri podczas leczenia.

Leczenie może zająć miesiące a nawet lata by całkowicie pozbyć się Cpn z ciała.


 

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